Achiron, A., Miron, G., Zilkha-Falb, R., Magalashvili, D., Dolev, M., Stern, Y., & Gurevich, M. (2016). Host cell virus entry mechanisms enhance anti-JCV-antibody switch in natalizumab-treated multiple sclerosis patients. Journal of Neurovirology, 22(6), 736-746. doi:10.1007/s13365-016-0445-4

Adak, A., & Khan, M.R. (2019).  An insight into gut microbiota and its functionalities. Cellular and Molecular Life Sciences, 76(3), 473-493. Epub 2018 Oct 13. PMID: 30317530. doi:10.1007/s00018-018-2943-4

Alcina, A., Abad-Grau, M.M., Fedetz, M., Izquierdo, G., Lucas, M., Fernández, O., N’dagire, D., Catalá-Rabasa, A., Ruiz, A., Gayán, J., Delgado, C., Arnal, C., & Matesanz, F. ( 2012).  Multiple sclerosis risk variant HLADRB1*1501 associates with high expression of DRB1 gene in different human populations. PLos One, 7(1), e29819. doi:10.1371/journal.pone.0029819

Allison, D.B., Shiffrin, R.M., & Stodden, V. (2018). Reproducibility of research: Issues and proposed remedies. Proceedings of the National Academy of Sciences, 115(11), 2561-2562. doi:10.1073/pnas.1802324115

Angelini, D.F., Serafini, B., Piras, E., Severa, M., Coccia, E.M., Rosicarelli, B., & Battistini, L. (2013). Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis. PLos Pathogens, 9(4), 1-16. doi:10.1371/journal.ppat.1003220

Anthony, W., & Gidugu, V. (2012). Systematic review of the effects of exercise and physical activity on psychological and quality of life outcomes for individuals with multiple sclerosis, 1996-2011. Boston: Boston University, Sargent College, Center for Psychiatric Rehabilitation. http://www.bu.edu/drrk/research-syntheses/multiple-sclerosis/effects-of-exercise/

Antony, J.M., van Marle, G., Opii, W., Butterfield, D.A., Mallet, F., Yong, V.W., & Power, C. (2004). Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nature Neuroscience, 7(10), 1088-1095. doi:10.1038/nn1319

Arai, N., Seki, E., Kojima, R., & Eguchi, H. (2019). Stainings of nerve tissues: Core curriculum of neuropathology. Tokyo Metropolitan Institute of Medical Science.   https://pathologycenter.jp/crrinpa/crrinpa10.html

Ascherio. A. (2013). Environmental factors in multiple sclerosis. Expert Review of Neurotherapeutics, 13(sup2), 3-9. doi:10.1586/14737175.2013.865866. https://www.ncbi.nlm.nih.gov/pubmed/24289836

Badihian, S., Manouchehri, N., & Badihian, N. (2017). More evidence is needed to show any role of cytomegalovisrus and varicella zoster virus in pathogenesis of multiple sclerosis. Journal Of Neuroimmunology, 313123-124. doi:10.1016/j.jneuroim.2017.09.006 

Banki, K., Colombo, E.,  Sia, F., Halladay, D., Mattson, D., Tatum, A., Massa, P., Phillips, P., and Perl, A. (1994).  Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. The Journal of Experimental Medicine, 180(5), 1649-1663. doi:10.1084/jem.180.5.1649

Barry, A., Cronin, O., Ryan, A. M., Sweeney, B., Yap, S. M., O'Toole, O., & Downer, E. J. (2016). Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology. Frontiers in physiology, 7(194). doi:10.3389/fphys.2016.00194

Bermejo-Jambrina, M., Eder, J., Helgers, L. C., Hertoghs, N., Nijmeijer, B. M., Stunnenberg, M., & Geijtenbeek, T. (2018). C-Type Lectin Receptors in Antiviral Immunity and Viral Escape. Frontiers in immunology, 9, 590. doi:10.3389/fimmu.2018.00590

Borkosky, S.S., Whitley, C., Kopp-Schneider, A., zur Hausen, H., deVilliers, E.M. (2012). Epstein-Barr virus stimulates torque teno virus replication: A possible relationship to multiple sclerosis. PLos One 7(2), e32160. doi:10.1371/journal.pone.0032160

Boullerne A. I. (2016). The history of myelin. Experimental neurology, 283(Pt B), 431–445. doi:10.1016/j.expneurol.2016.06.005

Bowman, S.A., Clemens, J.C., Martin, C.L., Anand, J., Steinfeldt, L.C., & Moshfegh, A.J. (2017). Added sugars intake of Americans: What we eat in America, NHANES 2013-2014. Food Surveys Research Group. Dietary Data Brief No. 18.

Brettschneider, J., Tumani, H., Kiechle, U., Muche, R., Richards, G., Lehmensiek, V., Ludolph, A., Otto, M. (2009). IgG Antibodies against Measles, Rubella, and Varicella Zoster Virus Predict Conversion to Multiple Sclerosis in Clinically Isolated Syndrome. PLoS ONE, 4(11), 1-5. 

Burks, J., Devald, B., Jankovsky, L., & Gerdes, J. (1980). Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients. Science (New York, N.Y.), 209(4459), 933-4. 

Calabrese, R., Zampieri, M., Mechelli, R., Annibali, V., Guastafierro, T., Ciccarone, F., Coarelli, G., Umeton, R., Salvetti, M., Caiafa, P. (2012). Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral blood. Multiple Sclerosis, 18(3), 299-304. PMID: 21878453. doi:10.1177/1352458511421055

Caprariello, A.V., Rogers, J.A., Morgan, M.L., Hoghooghi, V., Plemel, J.R., Koebel, A., Tsutsui, S., Dunn, J.F., Kotra, L.P., Ousman, S., Wee Yong, V., Stys, P.K. (2018). Biochemically altered myelin triggers autoimmune demyelination. Proc Natl Acad Sci U S A, 115(21), 5528–5533. doi:10.1073/pnas.1721115115

Carvajal-Zarrabal, O., Nolasco-Hipolito, C., Aguilar-Uscanga, M.G., Melo Santiesteban, G., Hayward-Jones, P.M., & Barradas-Dermitz, D.M. (2014). Effect of dietary intake of avocado oil and olive oil on biochemical markers of liver function in sucrose-fed rats. BioMed Res Intern, 2014, 1-8. doi:10.1155/2014/595479

Casiraghi, C., & Horwitz, M. (2013). Epstein-Barr virus and autoimmunity: The role of a latent viral infection in multiple sclerosis and systemic lupus erythematosus pathogenesis. Future Virology, 8(2), 173-182. doi:10.2217/fvl.12.136

Charvet, B., Pierquin, J., Brunel, J., Gorter, R., Quétard, C., Horvat, B., Amor, S., Portoukalian, J., & Hervé Perron, H. (2021). Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics. Virologica Sinica 36(1006–1026). https://doi.org/10.1007/s12250-021-00372-0

Chen, J., Chia, N., Kalari, K.R., Yao, J.Z., Novotna, M., Soldan, M.M.P., Luckey, D.H., Marietta, E.V., Jeraldo, P.R., Chen, X., Weinshenker, B.G., Rodriguez, M., Kantarci, O.H., Nelson, H., Murray, J.A., & Mangalam, A.K. (2016). Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls. Scientific Reports, 6(1). PMID: 27346372. PMCID: PMC4921909. doi:10.1038/srep28484

Choi, I.Y., Piccio, L., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., Suarez, J., Michalsen, A., Cross, A.H., Morgan, T.E., Wei, M., Paul, F., Bock, M., & Longo, V.D. (2016). A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Reports, 15(10), 2136–2146.  doi:10.1016/j.celrep.2016.05.009

Coico, R., & Sunshine, G. (2015). Immunology: A short course. Seventh Edition. New York: Wiley-Liss & Blackwell. ISBN: 978-1-118-39691-9

Constantinescu, C.S., Farooqi, N., O'Brien, K., & Gran, B. (2011). Experimental autoimmune encephalomyelitis (EAE) as model for multiple sclerosis (MS). Brit Jour of Pharm, 164(4), 1079-1106. doi:10.1111/j.1476-5381.2011.01302.x

Dalgas, U., & Stenager, E. (2012). Exercise and disease progression in multiple sclerosis: Can exercise slow down the progression of multiple sclerosis? Therapeutic Advance in Neurological Disorders, 5(2), 81–95. doi:10.1177/1756285611430719

Deckx, N., Lee, W.P., Berneman, Z.N., & Cools, N. (2013). Neuroendocrine immunoregulation in multiple sclerosis. Clinical & Developmental Immunology, 2013, 1-23. doi:10.1155/2013/705232

Delbue, S., Carluccio, S., & Ferrante, P. (2012). The long and evolving relationship between viruses and multiple sclerosis. Future Virology, 7(9), 871-883. http://dx.doi.org.proxy-iup.klnpa.org/10.2217/fvl.12.78

Dendrou, C.A., Fugger, L., & Friese, M.A. (2015). Immunopathology of multiple sclerosis. Nat Rev Immunology, (15)9, 545-558. doi:10.1038/nri3871

Dessau, R. B., Lisby, G., & Frederiksen, J. L. (2001). Coronaviruses in brain tissue from patients with multiple sclerosis. Acta Neuropathologica, 101(6), 601-604.  

de Weck, A. L. (1998). Delayed-Type Hypersensitivity. Encyclopedia of Immunology (Second Edition), Elsevier, 738-742. ISBN 9780122267659. https://doi.org/10.1006/rwei.1999.0195.

Dobberstein, Linda J. (2018). Multiple Sclerosis and Recent Findings with the Epstein-Barr Virus. Wellness Resources. https://www.wellnessresources.com/news/multiple-sclerosis-and-recent-findings-with-the-epstein-barr-virus-

Döring, A., Pfueller, C. F., Paul, F., & Dörr, J. (2011). Exercise in multiple sclerosis - an integral component of disease management. The EPMA journal, 3(1), 2. doi:10.1007/s13167-011-0136-4

Dorosty-Motlagh, A.R., Honarvar, N.M, Sedighiyan, M., & Abdolahi, M. (2016). The molecular mechanisms of vitamin A deficiency in multiple sclerosis. Journal of Molecular Neuroscience, 60, 82–90. doi:10.1007/s12031-016-0781-0

Dupuis, N., Curatolo, N., Benoist, J.F. & Auvin, S. (2015), Ketogenic diet exhibits anti‐inflammatory properties. Epilepsia, 56, e95-e98. doi:10.1111/epi.13038

Ehling, R., Di Pauli, F., Lackner, P., Rainer, C., Kraus, V., Hegen, H., Lutterotti, A., Kuenz, B., De Zordo, T., Schocke, M., Glatzl, S., Löscher, W.N., Deisenhammer, F., Reindl, M., & Berger, T. (2015). Impact of glatiramer acetate on paraclinical markers of neuroprotection in multiple sclerosis: A prospective observational clinical trial. Jour of Neuroim, 287, 98-105. doi:10.1016/j.jneuroim.2015.08.004

Encarnacion, A., Horie, N., Keren-Gill, H., Bliss, T.M., Steinberg, G.K., & Shamloo, M. (2011). Long-term behavioral assessment of function in an experimental model for ischemic stroke. Journal of Neuroscience Methods, 196(2), 247–257. doi:10.1016/j.jneumeth.2011.01.010

Engel-Yeger, B., DeLuca, J., Hake, P., & Goverover, Y. (2019). The role of sensory processing difficulties, cognitive impairment, and disease severity in predicting functional behavior among patients with multiple sclerosis. Disability Rehabilitation, 1-8. PMID: 31453721. doi:10.1080/09638288.2019.1653998

Eriksson, J., Kobelt, G., Gannedahl, M., & Berg, J. (2019). Association between disability, cognition, fatigue, EQ-5D-3L domains, and utilities estimated with different western European value sets in patients with multiple sclerosis. Value in Health, (22)2, 231-238. doi:10.1016/j.jval.2018.08.002

Evans, E., Piccio, L., & Cross, A.H. (2018). Use of vitamins and dietary supplements by patients with multiple sclerosis: A review. JAMA Neurology, 75(8), 1013–1021. doi:10.1001/jamaneurol.2018.0611

Falcão, A.M., Meijer, M., Scaglione, A., Rinwa, P., Agirre, E., Liang, J., Larsen, S.C., Heskol, A., Frawley, R., Klingener, M., Varas-Godoy, M., Raposo, A., Ernfors, P., Castro, D.S., Nielsen, M.L., Casaccia, P., & Castelo-Branco, G. (2019). PAD2-mediated citrullination contributes to efficient oligodendrocyte differentiation and myelination. Cell Reports, 27(4), 1090–1102. doi:10.1016/j.celrep.2019.03.108

Fletcher, J.M., Lalor, S.J., Sweeney, C.M., Tubridy, N., Mills, K.H. (2010). T cells in multiple sclerosis and experimental autoimmune encephalomyelitis. Clin Exp Immunol, 162(1), 1-11. doi:10.1111/j.1365-2249.2010.04143.x

Fraussen, J., Claes, N., de Bock, L., & Somers, V. (2014). Targets of the autoimmune response in multiple sclerosis. Autoimmunity Reviews, 13(11). doi:10.1016/j.autrev.2014.07.002

Friese, M.A., Montalban, X., Willcox, N., Bell, J.I., Martin, R., & Fugger, L. (2006). The value of animal models for drug development in multiple sclerosis. Brain. 129(Pt 8):1940-52. doi: 10.1093/brain/awl083. Epub 2006 Apr 24. PMID: 16636022.

Gajofatto, A., & Benedetti, M.D. (2015). Treatment strategies for multiple sclerosis: When to start, when to change, when to stop? World Journal of Clinical Cases, 3(7), 545–555. doi:10.12998/wjcc.v3.i7.545

Gasior, M., Rogawski, M. A., & Hartman, A. L. (2006). Neuroprotective and disease-modifying effects of the ketogenic diet. Behavioral Pharmacology, 17(5-6), 431–439. doi:10.1097/00008877-200609000-00009

Geddes, L. (2012). Virus RNA linked to multiple sclerosis. New Scientist, 213(2846), 15. 

Gentech, Inc. (2019). www.gene.com. © 2015 Genentech USA, Inc. All rights reserved. OCR/030217/0028. https://www.gene.com/stories/the-immune-system-in-multiple-sclerosis

Getts, D.R., Getts, M., Teague, K., Nicholas, J.C., & Miller, S.D. (2014). Infectious triggers of T cell autoimmunity. Chapter 19. The Autoimmune Diseases, 263-274. doi:10.1016/B978-0-12-384929-8.00019-8

Gerrard, B., Singh, V., Babenko, O., Gauthier, I., Wee Yong, V., Kovalchuk, I., Luczak, A., & Metz, G.A.S. (2017). Chronic mild stress exacerbates severity of experimental autoimmune encephalomyelitis in association with altered non-coding RNA and metabolic biomarkers. Neuroscience, 359, 299-307. doi:10.1016/j.neuroscience.2017.07.033

Gibson, G., Hutkins, R., Sanders, M.E., Prescott, S.L., Reimer, R.A., Salminen, S.J., Scott, K., Stanton, C., Swanson, K.S., Cani, P.D., Verbeke, K., & Reid, G. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology, (14)8, 491–502. doi:10.1038/nrgastro.2017.75

Giesser, B.S. (2015). Exercise in the management of persons with multiple sclerosis. Therapeutic Advances in Neurological Disorders, 8(3), 123–130. doi:10.1177/1756285615576663

Harrer, A., Wipfler, P., Pilz, G., Oppermann, K., Haschke-Becher, E., Afazel, S., & Sellner, J. (2015). Adaptive immune responses in a multiple sclerosis patient with acute varicella-zoster virus reactivation during treatment with fingolimod. Interna Jour of Mol Sci, 16(9), 21832-21845. doi:10.3390/ijms160921832

Hassani, A., Corboy, J.R., Al-Salam, S., & Khan, G. (2018). Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells. PLos One, 13(2), e0192109. doi:10.1371/journal.pone.0192109

Hewagama, A., & Richardson, B. (2009). The genetics and epigenetics of autoimmune diseases. Journal of Autoimmunity, 33(1), 3-11. doi:10.1016/j.jaut.2009.03.007

Hochstrasser, T., Jiangshan, Z., Rühling, S., Schmitz, C., & Kipp, M. (2018). Do pre-clinical multiple sclerosis models allow us to measure neurodegeneration and clinical progression?  Expert Review of Neurotherapeutics, (18)5, 351-353.  doi:10.1080/14737175.2018.1459190

Høglund, R.A., & Maghazachi, A.A. (2014). Multiple sclerosis and the role of immune cells. World Jour of Exp Med, 4(3), 27-37. doi:10.5493/wjem.v4.i3.27

Hohl, T. M. (2015). Cell-Mediated Defense against Infection. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases; 50-69.e6. ISBN 9781455748013. https://doi.org/10.1016/B978-1-4557-4801-3.00006-0.

Holmøy, T., Løken-Amsrud, K.I., Bakke, S.J., Beiske, A.G., Bjerve, K.S., Hovdal, H., Lilleås, F., Midgard, R., Pedersen, T., Benth, J.S, Torkildsen, O., Wergeland, S., Myhr, K.M., Michelsen, A.E., Aukrust, P., & Ueland, T. (2013). Inflammation markers in multiple sclerosis: CXCL16 reflects and may also predict disease activity. PLos One, 8(9), e75021. doi:10.1371/journal.pone.0075021

Hooke Laboratories, Inc. (2019). Protocols for EAE Induction by Active Immunization in C57BL/6 Mice and Appendix A: Mouse EAE Scoring Guide.   https://hookelabs.com/services/cro/eae/MouseEAEscoring.html, https://hookelabs.com/protocols/eaeAI_C57BL6.html

Hovanec, D., & Flanagan, T. (1983). Detection of antibodies to human coronaviruses 229E and OC43 in the sera of multiple sclerosis patients and normal subjects. Infection and Immunity, 41(1), 426-9.

Imitola, J., Chitnis, T., Khoury, S.J. (2006).  Insights Into the Molecular Pathogenesis of Progression in Multiple Sclerosis: Potential Implications for Future Therapies.  Arch Neurol. 2006;63(1):25-33. doi:10.1001/archneur.63.1.25

Immunopaedia.org. (2019). International union of immunological societies.  Immunology without borders.  Website: https://www.immunopaedia.org.za/glossary/

Institute of Medicine. (1998). Food and Nutrition Board. Dietary reference intakes: Thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. National Academy Press, Washington, DC. doi:10.17226/6015

Intahphuak, S., Khonsung, P., & Panthong, A. (2010).  Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil. Pharmaceutical Biology, (48)2, 151-157. doi:10.3109/13880200903062614

Janeway, C.A., Jr., Travers, P., Walport, M., & Capra, J.D. (2001). Immunobiology: The immune system in health and disease. 5th ed. Garland Science. Infectious Agents & How They Cause Disease, (21)4, 201. doi:10.1016/S0167-5699(00)01613-3

Jongen, P.J., Ter Horst, A.T., Brands, A.M. (2012). Cognitive impairment in multiple sclerosis.  Minerva Medica, 103(2), 73-96.

Joy, J.E. & Johnston, R.B., Jr. (2001). Institute of medicine (US) committee on multiple sclerosis: Current status and strategies for the future. National Academies Press (US). doi:10.17226/10031

Kennedy, H.S., Jones, C., 3rd, & Caplazi, P. (2013). Comparison of standard laminectomy with an optimized ejection method for the removal of spinal cords from rats and mice. Journal of Histotechnology, 36(3), 86–91. doi:10.1179/014788813X13756994210382

Khan, A., Kamran, S., Ponirakis, G., Akhtar, N., Khan, R., George, P., & Malik, R. A. (2018). Peripheral neuropathy in patients with multiple sclerosis. PloS one, 13(3), e0193270. doi:10.1371/journal.pone.0193270.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841750/

Kjølhede, T., Siemonsen, S., Wenzel, D., Stellmann, J.P., Ringgaard, S., Pedersen, B.G., Stenager, E., Petersen, T., Vissing, K., Heesen, C., Dalgas, U. (2018). Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? Mult Scler, 24(10), 1356-1365. doi:10.1177/1352458517722645

Kim, D.Y., Hao, J., Liu, R., Turner, G., Shi, F.D., & Rho, J.M. (2012). Inflammation-mediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLos One, 7(5), e35476. doi:10.1371/journal.pone.0035476

Kirkwood, C. (2015). Myelin: An overview. Source BrainFacts/SfN. Epub 24 Mar 2015.

Kjølhede, T., Siemonsen, S., Wenzel, D., Stellmann, J.P., Ringgaard, S., Pedersen, B.G., Stenager, E., Petersen, T., Vissing, K., Heesen, C., Dalgas, U. (2018). Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? Mult Scler, 24(10):1356-1365. doi: 10.1177/1352458517722645. Epub 2017 Jul 28.

Koch, M.W., Metz, L.M., & Kovalchuk, O. (2012). Epigenetic changes in patients with multiple sclerosis. Nature Reviews Neurology, 9(1), 35-43. doi:10.1038/nrneurol.2012.226

Kouwenhoven, M., Teleshova, N., Özenci, V., Press, R., & Link, H. (2001). Monocytes in multiple sclerosis: Phenotype and cytokine profile. Journal of Neuroimmunology, 112(1-2), 197-205. doi:10.1016/S0165-5728(00)00396-9

Kronenberg, M., & Rudensky, A. (2005). Regulation of immunity by self-reactive T cells. Nature, 435(7042), 598-604.

Lassmann, H., & Bradl, M. (2017). Multiple sclerosis: Experimental models and reality. Acta Neuropathologica, 133(2), 223-244. doi:10.1007/s00401-016-1631-4

Lassmann, H., & van Horssen, J. (2016). Oxidative stress and its impact on neurons and glia in multiple sclerosis lesions. BBA - Molecular Basis Of Disease, 1862(NEUROINFLAMMATION: A common denominator for stroke, multiple sclerosis and Alzheimer's disease), 506-510. doi:10.1016/j.bbadis.2015.09.018

Leong, E., Semple, S., Angley, M., Siebert, W., Petkov, J., & McKinnon, R. (2009). Complementary and alternative medicines and dietary interventions in multiple sclerosis: What is being used in South Australia and why?. Complementary Therapies In Medicine, 17216-223. doi:10.1016/j.ctim.2009.03.001

Levin, M.C. (2018). Other Primary Demyelinating Diseases. College of Medicine, University of Saskatchewan. Last full review/revision September 2018 by Michael C. Levin, MD. https://www.merckmanuals.com/professional/neurologic-disorders/demyelinating-disorders/overview-of-demyelinating-disorders?query=Other%20Primary%20Demyelinating%20Diseases

Levy, H., Assaf, Y., & Frenkel, D. (2010). Characterization of brain lesions in a mouse model of progressive multiple sclerosis. Experimental Neurology, 226(1), 148-158. doi:10.1016/j.expneurol.2010.08.017

Lichtash, C., Fung, J., Ostoich, K. C., & Ramos, M. (2020). Therapeutic use of intermittent fasting and ketogenic diet as an alternative treatment for type 2 diabetes in a normal weight woman: a 14-month case study. BMJ case reports, 13(7), e234223. doi:10.1136/bcr-2019-234223

Locri, F., Cammalleri, M., Pini, A., Dal Monte, M., Rusciano, D., & Bagnoli, P. (2018). Further evidence on efficacy of diet supplementation with fatty acids in ocular pathologies: Insights from the EAE model of optic neuritis. Nutrients, 10(10), 1447. doi:10.3390/nu10101447

Love S. (2006). Demyelinating diseases. Journal of clinical pathology, 59(11), 1151–1159. doi:10.1136/jcp.2005.031195. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860500/

Lundmark, F., Duvefelt, K., Lacobaeus, E., Kockum, I., Wallström, E., Khademi, M., Oturai, A., Ryder, L.P., Saarela, J., Harbo, H.F., Celius, E.G., Salter, H., Olsson, T., & Hillert, J. (2007). Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nature Genetics, 39(9), 1108-13. doi:10.1038/ng2106

Mack, C. L., Vanderlugt-Castaneda, C. L., Neville, K. L., & Miller, S. D. (2003). Microglia are activated to become competent antigen presenting and effector cells in the inflammatory environment of the Theiler's virus model of multiple sclerosis. Journal Of Neuroimmunology, 144(1/2), 68. doi:10.1016/j.jneuroim.2003.08.032

Magno, L.V., Collodetti, M., Tenza-Ferrer, H. & Romano-Silva, M.A. (2019). Cylinder test to assess sensory-motor function in a mouse model of Parkinson’s disease. Bio-protocol, 9(16), e3337. doi:10.21769/BioProtoc.3337

Magno, L.A.V., Tenza-Ferrer, H., Collodetti, M., Aguiar, M.F.G., Rodrigues, A.P.C., da Silva, R.S., Silva, J.D.P., Nicolau, N.F., Rosa, D.V.F., Birbrair, A., Miranda, D.M. & Romano-Silva, M.A. (2019). Optogenetic stimulation of the M2 cortex reverts motor dysfunction in a mouse model of Parkinson's disease.  Journal of Neuroscience, 39(17), 3234-3248. doi:10.1523/JNEUROSCI.2277-18.2019

Mayer, E.A. (2011). Gut feelings: The emerging biology of gut-brain communication. Nature Reviews Neuroscience, 12(8), 453–466. doi:10.1038/nrn3071

Maloni, H. (2018). Cognitive impairment in multiple sclerosis. The Journal for Nurse Practitioners, 14(3), 172-177. doi:10.1016/j.nurpra.2017.11.018

Manjaly, Z., Harrison, N., Critchley, H.D., Tri, D.C., Stefanics, G., Wenderoth, N., Lutterotti, A., Müller, A., & Stephan, K. (2019). Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 90(6), 642-651. doi:10.1136/jnnp-2018-320050

Manouchehrinia, A., Tanasescu, R., Kareem, H., Jerca, O., Jabeen, F., Shafei, R., & Constantinescu, C. (2017). Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis. Journal of Neurovirology, 23(6), 839-844. doi:10.1007/s13365-017-0569-1

Markovic-Plesea, S., Pinillab, C., Martinc, R. (2004). The initiation of the autoimmune response in multiple sclerosis. Clinical Neurology and Neurosurgery, (106)3, 218-222. https://www.sciencedirect.com/science/article/abs/pii/S0303846704000447

Marrie, R. A., Reider, N., Cohen, J., Stuve, O., Sorensen, P. S., Cutter, G., & Trojano, M. (2015). A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis. Multiple Sclerosis Journal, 21(3), 282-293. doi:10.1177/1352458514564490

Marrie, R. A., Reider, N., Cohen, J., Trojano, M., Sorensen, P. S., Cutter, G., & Stuve, O. (2015). A systematic review of the incidence and prevalence of sleep disorders and seizure disorders in multiple sclerosis. Multiple Sclerosis Journal, 21(3), 342-349. doi:10.1177/1352458514564486

Marta, M. (2009). Toll‐like receptors in multiple sclerosis mouse experimental models. Annals of the New York Academy of Sciences, 11731(1), 458-462. doi:10.1111/j.1749-6632.2009.04849.x

Martinez, B., & Peplow, P.V. (2020). Protective effects of pharmacological therapies in animal models of multiple sclerosis: A review of studies 2014–2019. Neural Regen Res 2020, (15)7, 1220-34. doi:10.4103/1673-5374.272572

Marzban, F., Azizi, G., Afraei, S., Sedaghat, R., Seyedzadeh, M. H., Razavi, A., & Mirshafiey, A. (2015). Kombucha tea ameliorates experimental autoimmune encephalomyelitis in mouse model of multiple sclerosis. Food & Agricultural Immunology, 26(6), 782-793. doi:10.1080/09540105.2015.1036353

Masullo, L., Papas, M., Cotugna, N., Baker, S., Mahoney, L., & Trabulsi, J. (2015). Complementary and Alternative Medicine Use and Nutrient Intake Among Individuals with Multiple Sclerosis in the United States. Journal Of Community Health, 40(1), 153-160. doi:10.1007/s10900-014-9913-z

McFarland, H.F. & Martin, R. (2007). Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 8: 913–919, 2007 [PubMed] [Google Scholar]

Mecha, M., Carrillo-Salinas, F.J., Mestre, L., Feliú, A., & Guaza, C. (2013). Viral models of multiple sclerosis: Neurodegeneration and demyelination in mice infected with Theiler's virus. Progress in Neurobiology, 101-102, 46-64. doi:10.1016/j.pneurobio.2012.11.003

Meier, U., Giovannoni, G., Tzartos, J.S., & Khan, G. (2012). Translational mini-review series on B cell subsets in disease. B cells in multiple sclerosis: Drivers of disease pathogenesis and Trojan horse for Epstein-Barr virus entry to the central nervous system? Clin & Exp Imm 167(1), 1-6. doi:10.1111/j.1365-2249.2011.04446.x

Mestas, J., Hughes, C.C.W. (2004). Of Mice and Not Men: Differences between Mouse and Human Immunology. The Journal of Immunology. 172 (5) 2731-2738; DOI: 10.4049/jimmunol.172.5.2731

Miljković, D., & Spasojević, I. (2013). Multiple sclerosis: Molecular mechanisms and therapeutic opportunities. Antioxidants & Redox Signaling, 19(18), 2286–2334. doi:10.1089/ars.2012.5068

Miner, & Diamond. (2016). Mechanisms of restriction of viral neuroinvasion at the blood–brain barrier. Current Opinion in Immunology, 38, 18-23. 

Misawa, S., Kuwabara, S., Mori, M., Hayakawa, S., Sawai, S., Hattori, T. (2008).  Peripheral nerve demyelination in multiple sclerosis. Clin Neurophysiol. 119(8):1829-1833. doi: 10.1016/j.clinph.2008.04.010. https://www.ncbi.nlm.nih.gov/pubmed/18495530

Miyamoto, K., Tanaka, N., Moriguchi, K., Ueno, R., Kadomatsu, K., Kitagawa, H., & Kusunoki, S. (2014). Chondroitin 6-O-sulfate ameliorates experimental autoimmune encephalomyelitis. Glycobiology, 24(5), 469-475. doi:10.1093/glycob/cwu014

Modica, C., Bergsland, N., Dwyer, M.,  Ramasamy, D., Carl, E., Zivadinov, R., Benedict, R.  (2016). Cognitive reserve moderates the impact of subcortical gray matter atrophy on neuropsychological status in multiple sclerosis.  Multiple Sclerosis Journal, Vol. 22(1) 36–42.  DOI: 10.1177/1352458515579443

Mohamed, K., & Koriem, M. (2016). Multiple sclerosis: New insights and trends. Asian Pac Jour of Trop Biomed, (6)5, 429-440. doi:10.1016/j.apjtb.2016.03.009

Montes, M., Zhang, X., Berthelot, L., Laplaud, D.A., Brouard, S., Jin, J., Rogan, S., Armao, D., Jewells, V., Soulillou, J.P., Markovic-Plese, S. (2009). Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells. Clin Immunol. 2009 Feb;130(2):133-44. doi: 10.1016/j.clim.2008.08.030. Epub 2008 Nov 5.

Morandi, E., Tarlinton, R.E., & Gran, B. (2015). Multiple sclerosis between genetics and infections: Human endogenous retroviruses in monocytes and macrophages. Frontiers in Immunology, 6, 647. doi:10.3389/fimmu.2015.00647

Moscarello, M.A., Lei, H., Mastronardi, F.G., Winer, S., Tsui, H., Li, Z., Ackerley, C., Zhang, L., Raijmakers, R., & Wood, D.D. (2013). Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis. Dis Mod & Mech, 6(2), 467–478. doi:10.1242/dmm.010520

Mousavi, E.S., Heydarpour, P., Reis, J., Amiri, M., Sahraian, M.A. (2017). Multiple sclerosis and air pollution exposure: Mechanisms toward brain autoimmunity. Med Hypotheses, 100, 23-30. doi:10.1016/j.mehy.2017.01.003

Muraro, P.A., Pasquini, M., Atkins, H.L. (2017). Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. JAMA Neurology, February 2017 doi: 10.1001/jamaneurol.2016.5867  www.sciencedaily.com/releases/2017/02/170220134738.htm

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., et al. (2014). Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 41, 14–20. doi: 10.1016/j.immuni.2014.06.008

Musa-Veloso, K., Rarama, E., Comeau, F., Curtis, R., & Cunnane, S. (2002). Epilepsy and the ketogenic diet: Assessment of ketosis in children using breath acetone. Pediatric Research, 52(3), 443–448. doi:10.1203/00006450-200209000-00023

Musse, A.A., Li, Z., Ackerley, C.A., Bienzle, D., Lei, H., Poma, R., Harauz, G., Moscarello, M.A., & Mastronardi, F.G. (2008). Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system. Dis Mod & Mech, 1(4-5), 229–240. doi:10.1242/dmm.000729

Multiple Sclerosis Collaborators, GBD 2016. (2019). Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology 2019, 18(3), 269–85. doi:10.1016/S1474-4422(18)30443-5

Nally, F. K., De Santi, C., & McCoy, C. E. (2019). Nanomodulation of Macrophages in Multiple Sclerosis. Cells, 8(6), 543. doi:10.3390/cells8060543

National Multiple Sclerosis Society (2018). Web.  https://www.nationalmssociety.org/What-is-MS/What-Causes-MS

National Multiple Sclerosis Society. (2019). https://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Guidebook-MS-and-Disability-Resource-for-Claims-Professionals.pdf, https://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Physical_Activity_For_People_With_Multiple_Sclerosis_Final.pdf, https://www.nationalmssociety.org/For-Professionals/Clinical-Care/About-MS/Interaction-of-Genetics-and-the-Environment/Environmental-Factors

National Multiple Sclerosis Society. (2020). Information about MS. Available at: https://www.nationalmssociety.org/For-Professionals/Clinical-Care/About-MS/Interaction-of-Genetics-and-the-Environment/Environmental-Factors

N'diaye, M. (2018). Immunological mechanisms regulating neuroinflammation : A role for C-type lectin receptors and vitamin D. (PhD Dissertation).  SwePub (National Library of Sweden). ISBN: 9789176769874

Nevin, K.G., & Rajamohan, T. (2012).  Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation.  Clinical Biochemistry, 37(9), 830-835. ISSN 0009-9120. doi:10.1016/j.clinbiochem.2004.04.010

Neurofit. (2019). Preclinical Research for CNS and PNS disorders.  67400 Illkirch-Graffenstaden – FRANCE. https://www.neurofit.com/tech-anim-cylinder.html

Nociti, V., Frisullo, G., Marti, A., Luigetti, M., Iorio, R., Patanella, A., & Batocchi, A. (2010). Epstein-Barr virus antibodies in serum and cerebrospinal fluid from multiple sclerosis, chronic inflammatory demyelinating polyradiculoneuropathy and amyotrophic lateral sclerosis. Journal of Neuroimmunology, 225(1/2), 149-152. doi:10.1016/j.jneuroim.2010.04.007

Nutritional profile of Bio-Serv Product # F3666. (2020). Bio-Serve, Flemington, NJ.  Ketogenic Diet, AIN-76A Modified, High Fat, Paste, 5 kg/Box

O’Connor, K., Weinstock-Guttman, B., Carl, E., Kilanowski, C., Zivadinov, R., & Ramanathan, M. (2012). Patterns of dietary and herbal supplement use by multiple sclerosis patients. Journal of Neurology, 259(4), 637–644. doi:10.1007/s00415-011-6226-3

Ods.od.nih.gov. (2016). Office of Dietary Supplements - Thiamin [online] Available at: https://ods.od.nih.gov/factsheets/Thiamin-HealthProfessional/

O'Gorman, C., Lucas, R., & Taylor, B. (2012). Environmental risk factors for multiple sclerosis: A review with a focus on molecular mechanisms. International Journal of Molecular Sciences, 13(9), 11718–11752. doi:10.3390/ijms130911718

Olival, G.S., Faria, T.S., Nali, L.H.S., De Oliveira, A.C., Casseb, J.S., Evidal, J.E., Ecavenaghi, V., Etilbery, C., Emoraes, L., Efink, M.C., Esumita, L., Eperron, H., & Romano, C.M. (2013).  Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: Absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigen.  Frontiers in Microbiology, 4. doi:10.3389/fmicb.2013.00172

Olsson, T., Barcellos, L. & Alfredsson, L. (2017). Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nature Reviews Neurology, 13, 25–36. doi:10.1038/nrneurol.2016.187

Orrell, R.W. (2005). Multiple sclerosis: The history of a disease. Journal of the Royal Society of Medicine, 98(6), 289.  PMCID: PMC1142241

Owens, G.P., & Bennett, J.L. (2012). Trigger, pathogen, or bystander: The complex nexus linking Epstein–Barr virus and multiple sclerosis. Multiple Sclerosis, 18(9), 1204-1208. doi:10.1177/1352458512448109

Pacheco-Alvarez, D., & Solórzano-Vargas, R.S. & Del Río, A.L. (2002). Biotin in metabolism and its relationship to human disease. Archives of Medical Research, 33(5), 439-47. doi:10.1016/S0188-4409(02)00399-5

Page, N., Klimek, B., De Roo, M., Steinbach, K., Soldati, H., Lemeille, S., Wagner, I., Kreutzfeldt, M., Di Liberto, G., Vincenti, I., Lingner, T., Salinas, G., Brück, W., Simons, M., Murr, R., Kaye, J., Zehn, D., Pinschewer, D.D., & Merkler, D. (2018). Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cells. Immunity, 48(5), 937-950. doi:10.1016/j.immuni.2018.04.005

Palmer A. M. (2013). Multiple sclerosis and the blood-central nervous system barrier. Cardiovascular psychiatry and neurology, 530356. doi:10.1155/2013/530356 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562587/

Paltser, G., & Dosch, H.M. (2013). Neuro-immune elements of inflammatory disease. ProQuest Dissertations and Theses. ProQuest Dissertations Publishing. Creation Date 2013, ISBN: 9781321389579. © ProQuest LLC All rights reserved

Paoli, A., Bosco, G., Camporesi, E.M., & Mangar, D. (2015). Ketosis, ketogenic diet and food intake control: A complex relationship. Frontiers in Psychology, 6, 27. doi:10.3389/fpsyg.2015.00027

Panawala, L. (2017). Difference between monoclonal and polyclonal antibodies. Research Gate, Pediaa.  Retrieved from:             https://www.researchgate.net/publication/320707210_Difference_Between_Monoclonal_and_Polyclonal_Antibodies

Passalacqua, K.D., Charbonneau, M.E., & O'Riordan, M. (2016). Bacterial metabolism shapes the host-pathogen interface. Microbiology Spectrum, 4(3). doi:10.1128/microbiolspec.VMBF-0027-2015

Pavsic, K., Pelicon, K., Ledined, A., Sega, S. (2015).  Short-term impact of fampridine on motor and cognitive functions, mood and quality of life among multiple sclerosis patients.  Clinical Neurology and Neurosurgery. Vol. 139, p35, 6 p.  DOI: 10.1016/j.clineuro.2015.08.023.

Penberthy, T., & Smith, R.G. (2018). Nutritional treatments for multiple sclerosis. Orthomolecular Medicine News Service. Retrieved on December 10, 2019 from: http://orthomolecular.org/resources/omns/v14n15.shtml

Petit, E., LaTouf, W.G., Coppi, M.V., Warnick, T.A., Currie, D., Romashko, I., Deshpande, S., Haas, K., Alvelo-Maurosa, J.G., Wardman, C., Schnell, D.J., Leschine, S.B., & Blanchard, J.L. (2013). Involvement of a bacterial microcompartment in the metabolism of fucose and rhamnose by Clostridium phytofermentans. PLos One, 8(1), e54337. doi:10.1371/journal.pone.0054337

Pinto-Medel, M.J., Oliver-Martos, B., Urbaneja-Romero, P., Hurtado-Guerrero, I., Ortega-Pinazo, J., Serrano-Castro, P., Fernández, Ó., & Leyva, L. (2017). Global methylation correlates with clinical status in multiple sclerosis patients in the first year of IFN beta treatment. Sci Rep, 7(1), 8727. doi:10.1038/s41598-017-09301-2

Poser, C.M. (1987). The peripheral nervous system in multiple sclerosis. Journal of the Neurological Sciences, Volume 79, Issue 1, 83 – 90. https://www.jns-journal.com/article/0022-510X(87)90262-0/pdf

Pyka-Fosciak, G., Stasiolek, M., & Litwin, J.A. (2018). Immunohistochemical analysis of spinal cord components in mouse model of experimental autoimmune encephalomyelitis. Folia Histochemica et Cytobiologica, 56(3), 151-158. Pubmed: 30187907. doi:10.5603/FHC.a2018.0018

Popescu, B.F., Pirko, I., & Lucchinetti, C.F. (2013). Pathology of multiple sclerosis: Where do we stand? Continuum: Lifelong Learning in Neurology, 19(4), 901–921. doi:10.1212/01.CON.0000433291.23091.65    

Rahn, K., Slusher, B., & Kaplin, A. (2012). Cognitive impairment in multiple sclerosis: A forgotten disability remembered. Cerebrum: The Dana Forum on Brain Science, 2012, 14. PMCID: PMC3574761. PMID: 23447800

Raine, C. S., Moore, G. R., Hintzen, R., & Traugott, U. (1988). Induction of oligodendrocyte proliferation and remyelination after chronic demyelination. Relevance to multiple sclerosis. Laboratory Investigation; A Journal Of Technical Methods And Pathology, 59(4), 467-476.

Ramasamy, R., Joseph, B., & Whittall, T. (2017). Potential molecular mimicry between the human endogenous retrovirus W family envelope proteins and myelin proteins in multiple sclerosis.  Imm Letters, 183, 79-85. doi:10.1016/j.imlet.2017.02.003

Rangel Oliveira, S., Colado Simão, A. N., Kallaur, A. P., Delicato de Almeida, E. R., Kaminami, Morimoto, H., Lopes, J., & Vissoci Reiche, E. M. (2014). Disability in patients with multiple sclerosis: Influence of insulin resistance, adiposity, and oxidative stress. Nutrition, 30(3), 268-273. doi:10.1016/j.nut.2013.08.001

Ransohoff, R. M. (2005). Natalizumab and PML. Nature Neuroscience, 8(10), 1275.

Rasband, M.N., Macklin, W.B., & Benjamins, J.A. (2012). Chapter 10: Myelin Structure and Biochemistry, Basic Neurochemistry. Academic Press, 180-199. doi:10.1016/B978-0-12-374947-5.00010-9

Reid, C.E., Li, H., Sur, G., Carmillo, P., Bushnell, S., Tizard, R., McAuliffe, M., Tonkin, C., Simon, K., Goelz, S., Cinque, P., Gorelik, L., & Carulli, J.P. (2011). Sequencing and analysis of JC virus DNA from natalizumab-treated PML patients. The Journal of Infectious Diseases, 204(2), 237–244. doi:10.1093/infdis/jir256

Regenold, W. T., Phatak, P., Makley, M. J., Stone, R. D., & Kling, M. A. (2008). Cerebrospinal fluid evidence of increased extra-mitochondrial glucose metabolism implicates mitochondrial dysfunction in multiple sclerosis disease progression. Journal Of The Neurological Sciences, (1-2), 106.

Rieckmann, P., O'Connor, P., Francis, G. S., Wetherill, G., & Alteri, E. (2004). Haematological effects of interferon-[beta]-1a (Rebif[R]) therapy in multiple sclerosis. Drug Safety, (10), 745

Riccio, P., & Rossano, R. (2015). Nutrition facts in multiple sclerosis. American Society for Neurochemistry, ASN neuro, 7(1), 1-20. doi:10.1177/1759091414568185

Rodriguez, J.M. (2001).  Course of introduction to the swine immunology. Dep. Legal: B-32.422-01. ISBN: 84-699-5917-4. jmvizcaino@vet.ucm.es

Roome, R.B., & Vanderluit, J.L. (2015). Paw-dragging: A novel, sensitive analysis of the mouse cylinder test.  JoVE, 98, e52701. doi:10.3791/52701

Rosche, B., Cepok, S., Stei, S., Vogel, F., Grummel, V., Hoffmann, S., & Hemmer, B. (2004). The role of the polio virus receptor and the herpesvirus entry mediator B genes for the development of MS. Journal of Neuroimmunology, 156(1/2), 171-177. doi:10.1016/j.jneuroim.2004.07.001

Rostami, A., & Ciric, B. (2013). Role of Th17 cells in the pathogenesis of CNS inflammatory demyelination. Journal of the Neurologic Sciences, 333(1-2), 76-87. doi:10.1016/j.jns.2013.03.002

Ruhrmann, S., Stridh, P., Kular, L., & Jagodic, M. (2015). Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?. International Journal Of Biochemistry And Cell Biology, 49. doi:10.1016/j.biocel.2015.05.010

Sanna, A., Huang, Y.M., Arru, G., Fois, M.L., Link, H., Rosati, G., & Sotgiu, S. (2008). Multiple sclerosis: Reduced proportion of circulating plasmacytoid dendritic cells expressing BDCA-2 and BDCA-4 and reduced production of IL-6 and IL-10 in response to herpes simplex virus type 1. Multiple Sclerosis Journal, 14(9), 1199-1207. doi:10.1177/1352458508094401

Sarchielli P, Greco L, Floridi A, Floridi A, Gallai V. Excitatory Amino Acids and Multiple Sclerosis: Evidence From Cerebrospinal Fluid. Arch Neurol.2003;60(8):1082-1088. doi:10.1001/archneur.60.8.1082.

Schallert, T., Fleming, S.M., Leasure, J.L., Tillerson, J.L., & Bland, S.T. (2000). CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury. Neuropharmacology, 39(5), 777-787. doi:10.1016/S0028-3908(00)00005-8

Schallert, T., & Woodlee, M.T. (2005).  Orienting and placing: In the behavior of the laboratory rat. Oxford University Press, 129-140. doi:10.1093/acprof:oso/9780195162851.003.0012

Schugar, R.C., Huang, X., Moll, A.R., Brunt, E.M., & Crawford, P.A. (2013). Role of choline deficiency in the fatty liver phenotype of mice fed a low protein, very low carbohydrate ketogenic diet. PLos One, 8(8), e74806. doi:10.1371/journal.pone.0074806

Scott, T. F., Gettings, E. J., Hackett, C. T., & Schramke, C. J. (2016). Specific clinical phenotypes in relapsing multiple sclerosis: The impact of relapses on long-term outcomes. Multiple Sclerosis And Related Disorders, 51-6. doi:10.1016/j.msard.2015.10.001

Shaharabani, R., Ram-On, M., Talmon, Y., Beck, R. (2018).  Pathological transitions in myelin membranes driven by environmental and multiple sclerosis conditions. Proceedings of the National Academy of Sciences, 2018; 201804275 DOI: 10.1073/pnas.1804275115. https://www.sciencedaily.com/releases/2018/10/181016132003.htm

Sequestered antigens hypothesis. (n.d.). (2019). Mosby's Medical Dictionary, 8th edition. (2009). Retrieved from https://medical-dictionary.thefreedictionary.com/sequestered+antigens+hypothesis

Smets, I., Fiddes, B., Garcia-Perez, J.E., He, D., Mallants, K., Liao, W., Dooley, J., Wang, G., Humblet-Baron, S., Dubois, B., Compston, A., Jones, J., Coles, A., Liston, A., Ban, M., Goris, A., & Sawcer, S. (2018). Multiple sclerosis risk variants alter expression of co-stimulatory genes in B cells. Brain, 141(3), 786-796. doi:10.1093/brain/awx372

Snaidero, N., & Simons, M. (2014). Myelination at a glance. Journal of Cell Science, 127(14), 2999-3004. doi:10.1242/jcs.151043

Socha, K., Kochanowicz, J., Karpi¿ska, E., Soroczy¿ska, J., Jakoniuk, M., Mariak, Z., & Borawska, M. H. (2014). Dietary habits and selenium, glutathione peroxidase and total antioxidant status in the serum of patients with relapsing-remitting multiple sclerosis. Nutrition Journal, 13(1), 144-154. doi:10.1186/1475-2891-13-62

Sotelo, J., Ordoñez, G., & Pineda, B. (2007). Varicella-zoster virus at relapses of multiple sclerosis. Jour of Neurol, 254(4), 493-500. doi:10.1007/s00415-006-0402-x

Sotelo, Julio (2008). Varicella zoster virus contributes to relapse in patients with multiple sclerosis. Nature Clinical Practice Neurology, 4(6), 291.

Sotelo, J., Ordonez, G., Pineda, B., & Flores, J. (2014). The participation of varicella zoster virus in relapses of multiple sclerosis. Clinical Neurology & Neurosurgery, 119, 44-48. doi:10.1016/j.clineuro.2013.12.020

Steinman, L., & Zamvil, S. (2005). Virtues and pitfalls of EAE for the development of therapies for multiple sclerosis. Trends in Immunology, Autoimmunity Special Issue, 26(11), 565-571. doi:10.1016/j.it.2005.08.014

Sternberg, Z. (2015). Genetic, epigenetic, and environmental factors influencing neurovisceral integration of cardiovascular modulation: Focus on multiple sclerosis. Neuromolecular Medicine, doi:10.1007/s12017-015-8375-5

Stoll, S.S., Nieves, C., Tabby, D.S., & Schwartzman, R. (2012). Use of therapies other than disease-modifying agents, including complementary and alternative medicine, by patients with multiple sclerosis: A survey study. Journal of American Osteopathic Association, 112(1), 22–28. PMID: 22302743

Stys, P.K. (2010). Multiple sclerosis: autoimmune disease or autoimmune reaction? Can J Neurol Sci. 2010 Sep;37 Suppl 2:S16-23. https://www.ncbi.nlm.nih.gov/pubmed/21246931

Sumowski, J.F., Benedict, R., Enzinger, C., Filippi, M., Geurts, J.J., Hamalainen, P., Hulst, H., Inglese, M., Leavitt, V.M., Rocca, M.A., Rosti-Otajarvi, E.M., & Rao, S. (2018). Cognition in multiple sclerosis: State of the field and priorities for the future. Neurology, 90(6), 278-288. doi:10.1212/WNL.0000000000004977

Sun, B., Chang, H.H., Salinger, A., Tomita, B., Bawadekar, M., Holmes, C.L., Shelef, M.A., Weerapana, E., Thompson, P.R., & Ho, I.C. (2019). Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight, 4(22), e129687. doi:10.1172/jci.insight.129687

Susuki, K. (2010). Myelin: A specialized membrane for cell communication. Nature Education, 3(9), 59.

Traynor, K. (2013). Oral therapy approved for multiple sclerosis. American Journal Of Health-System Pharmacy, 70(9), 744. doi:10.2146/news130031

Tryfonos, C., Mantzorou, M., Fotiou, D., Vrizas, M., Vadikolias, K., Pavlidou, E., & Giaginis, C. (2019). Dietary supplements on controlling multiple sclerosis symptoms and relapses: Current clinical evidence and future perspectives. Medicines, 6(3), 95. doi:10.3390/medicines6030095

Tullis, P. (2012).  The Zamboni Affect. New York Times, pMM44, Sunday magazine.  https://www.nytimes.com/2012/10/28/magazine/a-controversial-cure-for-multiple-sclerosis.html

Tyblova, M., Kalincik, T., Zikan, V., & Havrdova, E. (2015). Impaired ambulation and steroid therapy impact negatively on bone health in multiple sclerosis. European Journal Of Neurology, 22(4), 624-632. doi:10.1111/ene.12479

van der Star, B. J., Vogel, D. S., Kipp, M., Puentes, F., Baker, D., & Amor, S. (2012). In vitro and in vivo models of multiple sclerosis. CNS & Neurological Disorders Drug Targets, 11(5), 570-588.

van Horssen, J., van der Pol, S., Nijland, P., Amor, S., & Perron, H. (2016).  Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis. Multiple Sclerosis and Related Disorders, 8, 11-18. doi:10.1016/j.msard.2016.04.006

Van Munster, C. E., Jonkman, L. E., Weinstein, H. C., Uitdehaag, B. M., & Geurts, J. J. (2015). Gray matter damage in multiple sclerosis: Impact on clinical symptoms. Neuroscience, 446. doi:10.1016/j.neuroscience.2015.07.006

van Ooij, C. (2011). The SWEET life of pathogens. Nature Reviews Microbiology, 9(1), 4-5. doi:10.1038/nrmicro2499

Viana, P., Rodrigues, E., Fernandes, C., Matas, A., Barreto, R., Mendonça, M., & Geraldes, R. (2015). In MS: Chronic insomnia disorder in multiple sclerosis – a Portuguese multicentre study on prevalence, subtypes, associated factors and impact on quality of life. Multiple Sclerosis And Related Disorders, 4477-483. doi:10.1016/j.msard.2015.07.010

Vidali, S., Aminzadeh, S., Lambert, B., Rutherford, T., Sperl, W., Kofler, B., & Feichtinger, R. G. (2015). Mitochondria: The ketogenic diet--A metabolism-based therapy. The International Journal Of Biochemistry & Cell Biology, 6355-59. doi:10.1016/j.biocel.2015.01.022

Vogel, D. Y., Vereyken, E. J., Glim, J. E., Heijnen, P. D., Moeton, M., van der Valk, P., & Dijkstra, C. D. (2013). Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. Journal of neuroinflammation, 10, 35. doi:10.1186/1742-2094-10-35

von Geijer, L., & Ekelund, M. (2015). Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman: A case report. Journal of Medical Case Reports, 9, 224. doi:10.1186/s13256-015-0709-2

Walter, S. D., Ishikawa, H., Galetta, K. M., Sakai, R. E., Feller, D. J., Henderson, S. B., & Balcer, L. J. (2012). Original article: Ganglion Cell Loss in Relation to Visual Disability in Multiple Sclerosis. Ophthalmology, 1191250-1257. doi:10.1016/j.ophtha.2011.11.032

Wang, D., Bhat, R., Sobel, R. A., Huang, W., Wang, L., Olsson, T., & Steinman, L. (2014). Uncovering cryptic glycan markers in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). Drug Development Research, 75(3), 172-188. doi:10.1002/ddr.21169

Waxman, S. G. (2005). Multiple Sclerosis As a Neuronal Disease. Burlington, MA: Academic Press

Wei, L., Wasilewski, E., Chakka, S. K., Bello, A. M., Moscarello, M. A., & Kotra, L. P. (2013). Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model. Journal Of Medicinal Chemistry, 56(4), 1715-1722. doi:10.1021/jm301755q

Willis, J. (2017). A modified ketogenic diet attenuates motor disability and cognitive dysfunction in a murine model of multiple sclerosis (MS). Saint Vincent College, Latrobe, Pa. 15650.

Willis, S.N., Stadelmann, C., Rodig, S.J., Caron, T., Gattenloehner, S., Mallozzi, S.S., Roughan, J.E., Almendinger, S.E., Blewett, M.M., Brück, W., Hafler, D.A., & O’Connor, K.C. (2009). Epstein–Barr virus infection is not a characteristic feature of multiple sclerosis brain. Brain: A Journal of Neurology, 132(12), 3318-3328. doi:10.1093/brain/awp200

Woodlee, M.T., Kane, J.R., Chang, J., Cormack, L.K., & Schallert, T. (2008). Enhanced function in the good forelimb of hemi-Parkinson rats: Compensatory adaptation for contralateral postural instability? Experimental Neurology, 211(2), 511–517. doi:10.1016/j.expneurol.2008.02.024

Woodlee, M.T., & Schallert, T. (2006). The impact of motor activity and inactivity on the brain: Implications for the prevention and treatment of nervous-system disorders. Current Directions in Psychological Science, 15(4), 203-206. doi:10.1111/j.1467-8721.2006.00436.x

Wootla, B., Eriguchi, M., & Rodriguez, M. (2012). Is multiple sclerosis an autoimmune disease? Autoimmune Diseases, 2012, 1-12. ID969657. doi:10.1155/2012/969657 

Wuest, S., Mexhitaj, I., Chai, N., Romm, E., Scheffel, J., Xu, B., & Bielekova, B. (2014). A complex role of herpes viruses in the disease process of multiple sclerosis. PLos One, 9(8), e105434. doi:10.1371/journal.pone.0105434

Yadav, V., Shinto, L., & Bourdette, D. (2010). Complementary and alternative medicine for the treatment of multiple sclerosis. Expert review of clinical immunology, 6(3), 381–395. doi:10.1586/eci.10.12

Zackowski, K.M., Smith, S.A., Reich, D.S., Gordon-Lipkin, E., Chodkowski, B.A., Sambandan, D.R., Shteyman, M., Bastian, A.J., van Zijl, P.C., & Calabresi, P.A. (2009). Sensorimotor dysfunction in multiple sclerosis and column-specific magnetization transfer-imaging abnormalities in the spinal cord. Brain: A Journal of Neurology, 132(5), 1200–1209. doi:10.1093/brain/awp032

Zempleni, J., Wijeratne, S.S.K., & Kuroishi, T. (2012). Biotin. Present Knowledge in Nutrition. 10th edition. Washington, DC: Wiley-Blackwell, 359-74. doi:10.1002/9781119946045.ch23

Zhang, J., Zhang, Z.G., Li, Y., Ding, X., Shang, X., Lu, M., Elias, S.B., & Chopp, M. (2015). Fingolimod treatment promotes proliferation and differentiation of oligodendrocyte progenitor cells in mice with experimental autoimmune encephalomyelitis. Neurobiology of Disease, 76, 57-66. doi:10.1016/j.nbd.2015.01.006

Zheleznyakova, G.Y., Piket, E., Marabita, F., Kakhki, M.P., Ewing, E., Ruhrmann, S., Needhamsen, M., Jagodic, M., & Kular, L. (2017).  Epigenetic research in multiple sclerosis: Progress, challenges, and opportunities. Physiological Genomics, 49(9), 447-461. doi:10.1152/physiolgenomics.00060.2017

Zhou, J., & Hinton, David R. (2003). Mechanisms Contributing to Inflammatory Cell Entry into the Central Nervous System during Neurotropic Mouse Hepatitis Virus Induced Encephalomyelitis, ProQuest Dissertations and Theses.